DNA-Verified Saccharomyces boulardii

Supports Gastrointestinal-based Immunity*
Supports Integrity and Function of Mucosal Cells*
Supports Healthy Gut Flora*

Nuley’s Healthy Gut Optimizer is manufactured using a process that involves controlled temperature and low vacuum, eliminating the shock of
freeze-drying. The drying procedure, which does not modify the water
content of the preparation, slows down aging, cell deterioration, and
contamination, leading to increased stability and greater resistance to
gastric acid. This process does not require or contain dairy products or
lactose.
Saccharomyces boulardii (S boulardii) is a natural, non-pathogenic
yeast that may help support and maintain the healthy ecology of
the small and large intestines. In a 2010 systematic review and
meta-analysis of 31 randomized placebo-controlled treatment
arms in 27 trials comprising 5029 adults, “S boulardii was found
to be significantly efficacious and safe in 84% of those treatment
arms.” A study also suggested that S boulardii can be used safely
and effectively in children three months and older. A double-
blind, randomized, placebo controlled study of children ages 3-59
months produced statistically significant positive results suggesting
that S boulardii may play an important role in supporting normal
gastrointestinal function in young children.
Extensively researched and published in European and American
peer-reviewed journals, Saccharomyces boulardii appears to function
through several mechanisms of action. With regard to maintaining
normal GI function and transit time, research suggests that S boulardii
secretes a protease that may assist in directly degrading bacterial
toxins and stimulating antibody production against those toxins.
S boulardii is also believed to support the natural inflammatory
response, exert a trophic effect on intestinal mucosa, and positively
support the immune system. These actions further support and
help maintain the normal health and function of the intestinal brush
border.
This probiotic yeast appears to support normal gastrointestinal
flora and integrity; promote production of intestinal enzymes and
secretory IgA; and support cytokine balance through its effects on
IL-8, IL-6, IL-10, NF-kappaB, TNF-alpha, and PPAR-gamma.
Research suggests a role for S boulardii in the production of health-
promoting short-chain fatty acids, including butyrate. Research
suggests that butyrate, in turn, plays an important role in maintaining
the integrity, function, and normal flora of the intestines.
Following a multi-dose study in healthy volunteers, the concentration
of S boulardii in feces increased rapidly, reaching a steady state by
day three in all subjects. Following completion of administration, the
S boulardii population declined consistently and was cleared from the
bowel within five to seven days, indicating that the probiotic yeast did
not permanently colonize the gastrointestinal tract. Nuley’s Health Gut Optimizer provides 10 billion colony-forming units of S boulardii in a two-
capsule dose

Pro-biotic

Healthy Gut Optimizer

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